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1.
SARS-CoV-2 Variants and Vaccines.
Krause, Philip R; Fleming, Thomas R; Longini, Ira M; Peto, Richard; Briand, Sylvie; Heymann, David L; Beral, Valerie; Snape, Matthew D; Rees, Helen; Ropero, Alba-Maria; Balicer, Ran D; Cramer, Jakob P; Muñoz-Fontela, César; Gruber, Marion; Gaspar, Rogerio; Singh, Jerome A; Subbarao, Kanta; Van Kerkhove, Maria D; Swaminathan, Soumya; Ryan, Michael J; Henao-Restrepo, Ana-Maria.
N Engl J Med ; 385(2): 179-186, 2021 Jul 08.
Article in English | MEDLINE | ID: covidwho-1358382

ABSTRACT

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have increased transmissibility or virulence, the importance of efficient public health measures and vaccination programs will increase. The global response must be both timely and science based.


Subject(s)
COVID-19 Vaccines , COVID-19/prevention & control , SARS-CoV-2 , COVID-19/transmission , COVID-19 Vaccines/immunology , Humans , Immunogenicity, Vaccine , Mutation , SARS-CoV-2/pathogenicity , Spike Glycoprotein, Coronavirus/genetics , Virulence
2.
Placebo-Controlled Trials of Covid-19 Vaccines - Why We Still Need Them.
Krause, Philip R; Fleming, Thomas R; Longini, Ira M; Peto, Richard; Beral, Valerie; Bhargava, Balram; Cravioto, Alejandro; Cramer, Jakob P; Ellenberg, Susan S; Figueroa, J Peter; Halloran, Elizabeth; Henao-Restrepo, Ana M; Ryan, Michael J; Levine, Myron M; Nason, Martha; Nohynek, Hanna M; Plotkin, Stanley; Rees, Helen; Singh, Jerome A; Swaminathan, Soumya.
N Engl J Med ; 384(2): e2, 2021 Jan 14.
Article in English | MEDLINE | ID: covidwho-954038

Subject(s)
COVID-19 Vaccines , Placebos , Randomized Controlled Trials as Topic , Humans
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